2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Potassium Channel

Potassium Channel

Channel

KcsA

Potassium Channel

Related Products

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Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114690
    PNU-140975
    		Activator
    PNU-140975 (BVT.3531) is a novel and potent bioactive compound. PNU-140975 can reduce body weight and activates KATP channel in isolated arcuate neurons in rats.
    PNU-140975
  • HY-W010950S
    Flecainide-d3
    Flecainide-d3 is the deuterium labeled Flecainide. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT).
    Flecainide-d<sub>3</sub>
  • HY-110082
    Quinine hydrochloride
    Quinine (hydrochloride) is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine (hydrochloride) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
    Quinine hydrochloride
  • HY-D0143R
    Quinine (Standard)
    		Inhibitor
    Quinine (Standard) is the analytical standard of Quinine. This product is intended for research and analytical applications. Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
    Quinine (Standard)
  • HY-N0221S1
    Daurisoline-d5
    		Inhibitor
    Daurisoline-d5 is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.
    Daurisoline-d<sub>5</sub>
  • HY-17437AR
    Mefloquine (hydrochloride) (Standard)
    		Antagonist
    Mefloquine (hydrochloride) (Standard) is the analytical standard of Mefloquine (hydrochloride). This product is intended for research and analytical applications. Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research.
    Mefloquine (hydrochloride) (Standard)
  • HY-N14502
    Gambierol
    		Inhibitor
    Gambierol inhibits voltage-gated K++ channels in various excitable and non-excitable cells.
    Gambierol
  • HY-W010950R
    Flecainide (Standard)
    		Inhibitor
    Flecainide (Standard) is the analytical standard of Flecainide. This product is intended for research and analytical applications. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT).
    Flecainide (Standard)
  • HY-A0084R
    Procainamide (hydrochloride) (Standard)
    		Activator
    Procainamide (hydrochloride) (Standard) is the analytical standard of Procainamide (hydrochloride). This product is intended for research and analytical applications.
    Procainamide (hydrochloride) (Standard)
  • HY-B2136R
    Tannic acid (Standard)
    		Inhibitor
    Tannic acid (Standard) is the analytical standard of Tannic acid. This product is intended for research and analytical applications. Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
    Tannic acid (Standard)
  • HY-B0563R
    Ropivacaine (Standard)
    		Inhibitor
    Ropivacaine (Standard) is the analytical standard of Ropivacaine. This product is intended for research and analytical applications. Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is used for the research of neuropathic pain management.
    Ropivacaine (Standard)
  • HY-B1194R
    Tetramisole hydrochloride (Standard)
    		Agonist
    Tetramisole hydrochloride (Standard) is the analytical standard of Tetramisole (hydrochloride). This product is intended for research and analytical applications. Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure.
    Tetramisole hydrochloride (Standard)
  • HY-133925
    6-O-Desmethyl donepezil
    		Inhibitor
    6-O-Desmethyl donepezil is the metabolite of Donepezil (HY-14566). 6-O-Desmethyl donepezil is an inhibitor for hERG channel with an IC50 of 1 μM.
    6-O-Desmethyl donepezil
  • HY-117255
    ZM260384
    ZM260384 is a KATP channel opener that accelerates metabolism and inhibits the decline of guinea pig isolated diaphragm function, thereby affecting muscle contraction. ZM260384 can be used to study muscle function under hypoxic conditions.
    ZM260384
  • HY-B0254R
    Glipizide (Standard)
    		Inhibitor
    Glipizide (Standard) is the analytical standard of Glipizide. This product is intended for research and analytical applications. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans.
    Glipizide (Standard)
  • HY-B1193R
    Terfenadine (Standard)
    		Inhibitor
    Terfenadine (Standard) is the analytical standard of Terfenadine. This product is intended for research and analytical applications. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
    Terfenadine (Standard)
  • HY-17504BS2
    Rosuvastatin-13C,d3 sodium
    		Inhibitor
    Rosuvastatin-13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
    Rosuvastatin-<sub>13</sub>C,d<sub>3</sub> sodium
  • HY-167866
    Ersentilide
    		Inhibitor
    Ersentilide, a benzamide derivative, is a is a β1-adrenoceptor antagonist and Ikr blocker. Ersentilide is effective in several intact animal models of arrhythmia.
    Ersentilide
  • HY-18172B
    (-)-KCC2 blocker 1
    		Control 99.19%
    (-)-KCC2 blocker 1 is an enantiomer of KCC2 blocker 1 (HY-18172). KCC2 blocker 1 (compound 13) is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM.
    (-)-KCC2 blocker 1
  • HY-N1933R
    Allocryptopine (Standard)
    		Inhibitor
    Allocryptopine (Standard) is the analytical standard of Allocryptopine. This product is intended for research and analytical applications. Allocryptopine, a derivative of tetrahydropalmatine, is extracted from Macleaya cordata (Thunb.) Pers. Papaveraceae. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current.
    Allocryptopine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity